Although mutation provides the fuel for phenotypic evolution, it also imposes a substantial burden on fitness through the production of predominantly deleterious alleles, a matter of concern from a human-health perspective. [. . .] a consideration of the long-term consequences of current human behavior for deleterious-mutation accumulation leads to the conclusion that a substantial reduction in human fitness can be expected over the next few centuries in industrialized societies unless novel means of genetic intervention are developed.I know Hamilton expressed similar concerns, but to the extent accelerated accumulation of deleterious mutations under modern conditions is a real/serious problem this author's suggestion of "multigenerational cryogenic storage and utilization of gametes and/or embryos" seems preferable to some of Hamilton's goofier "solutions" (such as marrying HIV- Nairobi prostitutes to protect one's offspring from impending AIDS epidemic). I'm not too worried about imminent mutational meltdown (some modern "problems" like antibiotics may be in the process of solving themselves), but from a strictly conservationist or even historical standpoint, large-scale, long-term storage of human genetic and/or gametic material makes sense. If we can see the need for plants and animals, why not for ourselves?
Genetic deterioration of modern populations?
A post by Notus Wind brought this paper to my attention: