Slide at 7:20:
"Rare [does not necessarily equal] Deleterious
MSTN: Lean muscles
LRP5: Extra-strong bones
PCSK9: Greatly reduced risk of heart disease
Embrace the extremes: informative, easy, powerful"
Conclusion: "So anyway we and others are sequencing these long-lived animals and humans and we hope this will be part of a bigger project to measure and design humans going forward."